Laforin/EPM2A Antibody (4A12) - Azide and BSA Free

Western Blot: Laforin/EPM2A Antibody (4A12) [H00007957-M01] - EPM2A monoclonal antibody (M01), clone 4A12. Analysis of EPM2A expression in PC-12.

ELISA: Laforin/EPM2A Antibody (4A12) [H00007957-M01] - Detection limit for recombinant GST tagged EPM2A is approximately 3ng/ml as a capture antibody.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IP
• Clone: 4A12
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Laforin/EPM2A Antibody (4A12) - Azide and BSA Free Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: EPM2A (NP_001018051, 101 a.a. ~ 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIV
• Specificity: EPM2A - epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) (4A12)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: EPM2A
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
  • Western Blot
• Application Notes: Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Laforin/EPM2A Antibody (4A12) - Azide and BSA Free

• EC 3.1.3.16
• EC 3.1.3.48
• epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
• epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
• EPM2
• EPM2A
• Lafora PTPase
• Laforin
• LAFPTPase
• LD
• LDE
• MELF

Background

This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Laforin/EPM2A Antibody (H00007957-M01)(1)

Publication using H00007957-M01

• Sherwood AR, Johnson MB, Delgado-Escueta AV, Gentry MS. A Bioassay for Lafora Disease and Laforin Glucan Phosphatase Activity. Clin Biochem. 2013-09-06 [PMID: 24012855]

Bioinformatics

• Gene Symbol: EPM2A
• Entrez:
  • 7957(Human)
• Uniprot:
  • NP_001018051(Human)