Kv7.5 Antibody

Product Discontinued

Kv7.5 Antibody Summary

• Immunogen: Peptide with sequence C-ESTDALSLPHVKLK corresponding to C-Terminus according to NP_001153602.1, NP_001153604.1, NP_1153605.1, NP_001153606.1.
• Epitope: C-Terminus
• Specificity: This antibody is expected to cross-react with isoform 1, 2, 3, 4 and 5 (NP_062816.2; NP_001153602.1; NP_001153604.1; NP_1153605.1; NP_001153606.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: KCNQ5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:64000
• Application Notes: WB: Preliminary experiments gave an approx. 22 kDa band in human brain (hippocampus and cerebral cortex) and human skeletal muscle lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 102 kDa band according to NP_062816.2. The 22 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Kv7.5 Antibody

• KCNQ5
• KQT-like 5
• Kv7.5
• potassium channel protein
• Potassium channel subunit alpha KvLQT5
• potassium voltage-gated channel subfamily KQT member 5
• potassium voltage-gated channel, KQT-like subfamily, member 5
• Voltage-gated potassium channel subunit Kv7.5

Background

KCNQ5 is a gene that codes for a protein that is thought to be important in the regulation of neuronal excitability, which has 5 isoforms, with lengths of 932, 923, 942, 427, and 822 amino acids and weights of approximately 102, 101, 104, 45, and 90 kDa respectively. Current studies are being done on diseases and disorders related to this gene including pharyngitis, cerebritis, schizophrenia, and neuronitis. KCNQ5 has also been shown to have interactions with CALM1, CALM2, CALM3, DISC1, and KCNQ3 in pathways such as the synaptic transmission-ion currents, dopamine-DARPP32 feedback, potassium channels, and celecoxib pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kv7.5 Antibody (NBP1-36968)(1)

Publication using NBP1-36968

• Schuetz F, Kumar S, Poronnik P, Adams DJ. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. Am J Physiol Cell Physiol 2008-07-01 [PMID: 18463232]

Bioinformatics

• Gene Symbol: KCNQ5
• Entrez:
  • 56479(Human)
  • 226922(Mouse)
  • 259273(Rat)
• Uniprot:
  • NP_062816.2(Human)