Kv7.3 Antibody

• Reactivity: Hu, Mu, Rt, Po
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Kv7.3 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence C-SDSVWTPSNKPI corresponding to C-Terminus according to NP_004510.1.
• Epitope: C-Terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: KCNQ3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments gave an approx. 23 kDa band in human brain (cerebral cortex, amygdala, hippocampus) lysates after 0.3ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 96.7 kDa band according to NP_004510.1. The 23 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Kv7.3 Antibody

• BFNC2
• EBN2
• KCNQ3
• KQT-like 3
• Kv7.3
• Potassium channel subunit alpha KvLQT3
• potassium channel, voltage-gated, subfamily Q, member 3
• potassium voltage-gated channel subfamily KQT member 3
• potassium voltage-gated channel, KQT-like subfamily, member 3
• Voltage-gated potassium channel subunit Kv7.3

Background

KCNQ3 is a gene that codes for a protein with two isoforms, measuring 872 and 752 amino acids in length, with weights of approximately 97 and 85 kDa respectively. KCNQ3 is thought to be important in the regulation of neuronal excitability. Current studies are being done one several diseases and disorders linked to this gene including convulsions, myokymia with neonatal epilepsy, juvenile myoclonic epilepsy, generalized epilepsy, benign neonatal seizures, neuronitis, migraine, pharyngitis, and ataxia. KCNQ3 has also been shown to have interactions with CALM1, CALM2, CALM3, KCNQ4, and KCNQ2 in pathways such as the synaptic transmission-ion currents, L1CAM interactions, potassium channels, and celecoxib pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kv7.3 Antibody (NBP1-36967)(1)

Publication using NBP1-36967

• Ekberg J, Schuetz F, Boase NA et al. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem 2007-04-20 [PMID: 17322297]

Bioinformatics

• Gene Symbol: KCNQ3
• Entrez:
  • 3786(Human)
  • 110862(Mouse)
  • 29682(Rat)
• Uniprot:
  • NP_004510.1(Human)