Kv7.2 Antibody

Product Discontinued

Kv7.2 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: FYATNLSRTDLHSTWQYYERTVTVPMYRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEA
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNQ2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Kv7.2 Antibody

• BFNC
• BFNS1
• EBN
• EBN1
• EIEE7
• ENB1
• HNSPC
• KCNA11
• KCNQ2
• KQT-like 2
• Kv7.2
• KVEBN1
• neuroblastoma-specific potassium channel protein
• Neuroblastoma-specific potassium channel subunit alpha KvLQT2
• potassium voltage-gated channel subfamily KQT member 2
• potassium voltage-gated channel, KQT-like subfamily, member 2
• Voltage-gated potassium channel subunit Kv7.2

Background

KCNQs are members of the voltage dependent non inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1 to 5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M current. Inhibition of M current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for Kv7.2 Antibody (NBP1-88645) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Musaad Alshammari ICC Mouse 08/08/2017

Summary

• Application: Immunocytochemistry
• Sample Tested: Adult mouse brain tissue
• Species: Mouse
• Lot: r06851

Comments

• Comments: 1%PFA fixed brain Tissue

Bioinformatics

• Gene Symbol: KCNQ2