Kir2.2 Antibody

Product Discontinued

Kir2.2 Antibody Summary

• Immunogen: A synthetic peptide from the cytoplasmic domain of human KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the immunogen.
• Specificity: Specific for KCNJ12.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNJ12
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 10-50 ug/ml
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Reactivity Notes

Human. Other species not yet tested.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (1x)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: IgG purified
• Reconstitution Instructions: Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for Kir2.2 Antibody

• ATP-sensitive inward rectifier potassium channel 12
• hIRK
• hIRK1
• hkir2.2x
• Inward rectifier K(+) channel Kir2.2
• Inward rectifier K(+) channel Kir2.2v
• inward rectifier K(+) channel Kir2.6
• IRK2
• IRK-2
• IRK2IRK-2
• KCNJ12
• kcnj12x
• KCNJN1
• KCNJN1FLJ14167
• Kir2.2
• Kir2.2v
• Potassium channel, inwardly rectifying subfamily J member 12
• potassium inwardly-rectifying channel, subfamily J, inhibitor 1
• potassium inwardly-rectifying channel, subfamily J, member 12

Background

FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.; Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.; Subcellular location: Membrane, Multi-pass membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNJ12
• Entrez:
  • 3768(Human)