Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, NULL
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Tissue specificity: Highest level in cerebellum. Moderately found in kidney, forebrain and skeletal muscle. Not detected in uterus, liver and pancreas. Subcellular location: Membrane, Multi-pass membrane protein.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
3768 |
| Alternate Names |
- ATP-sensitive inward rectifier potassium channel 12
- hIRK
- hIRK1
- hkir2.2x
- Inward rectifier K(+) channel Kir2.2
- Inward rectifier K(+) channel Kir2.2v
- inward rectifier K(+) channel Kir2.6
- IRK2IRK-2
- kcnj12x
- KCNJN1FLJ14167
- Kir2.2
- Kir2.2v
- Potassium channel, inwardly rectifying subfamily J member 12
- potassium inwardly-rectifying channel, subfamily J, inhibitor 1
- potassium inwardly-rectifying channel, subfamily J, member 12
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