KDM2B Antibody

Product Discontinued

KDM2B Antibody Summary

• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FBXL10. The exact sequence is proprietary.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KDM2B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 153 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7), 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for KDM2B Antibody

• [Histone-H3]-lysine-36 demethylase 1B
• CXXC2
• CXXC2F-box protein FBL10
• CXXC-type zinc finger protein 2
• FBL10
• F-box and leucine-rich repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
• F-box protein FBL10
• FBXL10
• JHDM1B
• JHDM1BF-box/LRR-repeat protein 10
• JmjC domain-containing histone demethylation protein 1B
• jumonji C domain-containing histone demethylase 1B
• Jumonji domain-containing EMSY-interactor methyltransferase motif protein
• KDM2B
• lysine (K)-specific demethylase 2B
• lysine-specific demethylase 2B
• NDY1
• PCCX2
• PCCX2EC 1.14.11.27
• protein containing CXXC domain 2
• Protein JEMMA
• Protein-containing CXXC domain 2

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for KDM2B Antibody (NBP2-14954)(1)

Publication using NBP2-14954

• Zhou Q, Zhang Y, Wang B et al. KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling Cell. Mol. Immunol. 2019-06-13 [PMID: 31197256]

Bioinformatics

• Gene Symbol: KDM2B
• Uniprot:
  • Q8NHM5(Human)