Kallikrein 11 Antibody (371604) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 371604
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 647

Kallikrein 11 Antibody (371604) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Kallikrein 11 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 11 Antibody (371604) [Alexa Fluor™ Plus 647]

• EC 3.4.21
• EC 3.4.21.-
• EC 3.4.21.4
• Hippostasin
• hK11
• Kallikrein 11
• kallikrein-related peptidase 11
• KLK11
• MGC33060
• PRSS20kallikrein-11
• Serine protease 20
• TLSPhippostasin
• Trypsin-like protease

Background

As a member of human tissue kallikrein family, Kallikrein 11, also known as hippostasin, trypsin-like serine protease and PRSS20, is encoded by the KLK11 gene (1). Two alternatively spliced forms exist, resulting in 250 (isoform 1) and 282 (isoform 2) amino acid sequences,respectively (2-5). Isoform 1 consists of a signal peptide (residues 1-18), a short pro peptide (residues 19-21) and the mature chain (residues 22-250). Isoform 2 is identical to isoform 1, except that a 32 amino acid segment is inserted in isoform 2 before residue 1 in isoform 1. Isoform 1 is predominantly expressed in brain whereas isoform 2 is preferentially expressed in prostate. KLK11 is a novel marker for ovarian and prostate cancer carcinomas (6-8). Recombinant human (rh) KLK11, after being activated by thermolysin, is active against a thioester substrate. This activity can be inhibited by AEBSF (R&D Systems, Catalog # EI001), dichloroisocoumarin, and aprotinin. rhKLK11 produced by R&D Systems corresponds to isoform 1.

1. Yousef, G.M. and E.P. Diamandis (2001) Endocrine Rev. 22:184.
2. Yoshida, S. et al. (1998) Biochim. Biophys. Acta 1399:225. 
3. Yousef, G.M. et al. (2000) Genomics 63:88.
4. Mitsui, S. et al. (2000) Biochem. Biophys. Res. Commun. 272:205.
5. Gan, L. et al. (2000) Gene 257:119.
6. Diamandis, E.P. et al. (2002) Cancer Res. 62:295.
7. Nakamura, T. et al. (2003) Urology 61:1042.
8. Borgono, C.A. et al. (2003) Int. J. Cancer 106:605.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.