IRS1 Antibody [Alexa Fluor® 405]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Alexa Fluor 405

Order Details

IRS1 Antibody [Alexa Fluor® 405] Summary

Immunogen
E. coli-derived recombinant human IRS1
Ala801-Ala1020
Accession # P35568
Specificity
Detects human, mouse, and rat IRS1 in Western blots.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Buffer
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IRS1 Antibody [Alexa Fluor® 405]

  • HIRS-1
  • insulin receptor substrate 1
  • IRS1
  • IRS-1

Background

IRS1 (Insulin Receptor Substrate 1) is a cytoplasmic protein that participates in the insulin signaling pathway. It is phosphorylated by the insulin receptor upon binding of insulin and subsequently associates with several SH2-domain-containing proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for IRS1 Antibody (AF3978V) (0)

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Secondary Antibodies

 

Isotype Controls

Additional IRS1 Products

Blogs on IRS1.

Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6
By Jamshed Arslan, Pharm. D., PhD. Insulin resistance in adipocytes is a major feature of metabolic syndrome   . Disrupted adipose tissue metabolism can lead to accumulation of lipid intermediates in insul...  Read full blog post.

Signalling Advances in Adiponectin Antibody Research
Adiponectin is an adipocytokine protein that positively regulates metabolism of lipids and glucose by suppressing glucose production from the liver, stimulating insulin sensitivity, and increasing the rate of fatty acid oxidation and glucose uptake. I...  Read full blog post.

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