IP3R1 Antibody

Western Blot: IP3R1 Antibody [H00003708-A01] - Detection against Immunogen (37.99 KDa) .

Product Discontinued

IP3R1 Antibody Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: ITPR1 (NP_002213, 2470 a.a. - 2577 a.a.) partial recombinant protein with GST tag. EHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHI
• Specificity: ITPR1 - inositol 1,4,5-triphosphate receptor, type 1
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: ITPR1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Use in ICC/IF reported in scientific literature (PMID:35242014) The quality control of this antibody is limited to WB on the immunizing protein. It has been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for IP3R1 Antibody

• DKFZp313E1334
• DKFZp313N1434
• inositol 14,5-triphosphate receptor, type 1
• inositol 14,5-trisphosphate receptor type 1
• InsP3R1
• IP3 receptor isoform 1
• IP3 receptor
• IP3R 1
• IP3R
• IP3R1
• ITPR1
• SCA15
• SCA16
• spinocerebellar ataxia 15
• spinocerebellar ataxia 16
• Type 1 inositol 14,5-trisphosphate receptor
• Type 1 InsP3 receptor

Background

IP3R1 (inositol 1,4,5-triphosphate receptor type 1) is an intracellular calcium release channel that mediates calcium release from the endoplasmic reticulum. There are 3 mammalian InsP3R receptors: Insp3R1, Insp3R2, and Insp3R3. Defects in the gene which encodes InsP3R1, ITPR1, are the cause of spinocerebellar ataxia type 15 (SCA15).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IP3R1 Antibody (H00003708-A01)(1)

Publication using H00003708-A01

• SAnchez TriviNo C, Landinez M, Duran S et al. Modulation of Gq/PLC-Mediated Signaling by Acute Lithium Exposure Frontiers in Cellular Neuroscience 2022-02-15 [PMID: 35242014] (ICC/IF, Human)

Bioinformatics

• Gene Symbol: ITPR1
• Entrez:
  • 3708(Human)
• OMIM:
  • 147265(Human)
• Uniprot:
  • NP_002213(Human)