ILT1/CD85h/LILRA2 Antibody (600002) [Alexa Fluor® 700]

• Applications: WB
• Clone: 600002
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

ILT1/CD85h/LILRA2 Antibody (600002) [Alexa Fluor® 700] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LILRA2/CD85h/ILT1
  Pro17-Ser437
  Accession # Q8N149
• Specificity: Detects human LILRA-2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) LILRA-1, rhLILRA-3, rhLILRA-4, rhLILRA-5, rhLILRA-6, rhILT-2, rhILT-4, or rhILT-5 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Immune-like transcript 1 (ILT1), also known as leukocyte immunoglobulin-like receptor 7 (LIR-7), leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2), and CD85H, is a 51 kDa (unglycosylated) type I transmembrane glycoprotein and member of the leukocyte immunoglobulin-like receptor family. Human ILT1 is synthesized as a 483 amino acid (aa) precursor that contains a 23 aa signal sequence, a 426 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 13 aa cytoplasmic region. The ECD contains four Ig-like C2-type domains and seven potential sites for N-linked glycosylation. A splice variant produces a second isoform that has a one aa substitution for aa 419-436 in the longer form. There are no murine orthologs for human ILT1. ILT1 may act as a receptor for class I MHC antigens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.