IL-4I1 Antibody (1003808) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 1003808
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 647

IL-4I1 Antibody (1003808) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human IL-4I1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-4I1 Antibody (1003808) [Alexa Fluor™ Plus 647]

• Fig-1 protein
• FIG1
• hFIG1
• IL4I1
• IL-4I1
• IL4-induced protein 1
• interleukin 4 induced 1
• interleukin four induced 1
• LAAO
• L-amino-acid oxidase
• LAO
• UNQ636/PRO1265

Background

Interleukin 4 induced protein 1 (IL-4I1), also known as protein FIG-1 and L-amino acid oxidase, is encoded by a B-cell IL-4-inducible gene, FIG1, and is highly expressed in primary metastinal B-cell lymphomas (1-4). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL-4I1 has L-amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hIL-4I1 inhibited the proliferation of CD3‑stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5). Its inhibitory effect was dependent on enzymatic activity and H₂O₂ production. Its restricted expression to lymphoid tissues indicates that it may play an important function in the immune system (1, 4).

1. Chu, C.C. and W.E. Paul. (1997) Proc. Natl. Acad. Sci. USA 94:2507.
2. Mason, J.M. et al. (2004) J. Immunol. 173:4561.
3. Chavan, S.S. et al. (2002) Biochim. Biophys. Acta. 1576:70.
4. Copie-Bergman, C. et al. (2003) Blood 101:2756.
5. Boulland, M.L. et al. (2007) Blood 110:220.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.