IL-28R alpha/IFN-lambda R1 Antibody

Immunohistochemistry: IL-28 R alpha/IFN-lambda R1 Antibody [NB100-741] - Immunohistochemistry with goat antibody to CRF-2-12 on paraffin section of mouse spleen.

Product Discontinued

IL-28R alpha/IFN-lambda R1 Antibody Summary

• Immunogen: Synthetic peptide: LPGLGSPPNVTYFVTYQSYIKTGWRPVEH, corresponding to N terminal amino acids 44-72 of Mouse IL28 Receptor alpha.
• Localization: Type I membrane protein
• Specificity: This recognizes the N-terminus of mouse CRF-2-12 (IL-28 receptor alpha) protein. This is likely to recognize rat CRF-2-12 (IL-28 receptor alpha) protein due to sequence similiarity. The peptide sequence is < 50 % identical to other sequences in GenBank.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IFNLR1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:50000
  • Flow Cytometry 1:10
  • Immunohistochemistry 1:150
  • Immunohistochemistry-Paraffin 1:150

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for IL-28R alpha/IFN-lambda R1 Antibody

• class II cytokine receptor CRF2/12
• CRF2/12
• CRF2-12
• Cytokine receptor class-II member 12
• Cytokine receptor family 2 member 12
• IFN-lambda R1
• IFN-lambda receptor 1
• IFN-lambda-R1
• IFNLR
• IFNLR1
• IL-28 R alpha
• IL-28 receptor subunit alpha
• IL28R alpha
• IL-28R1
• IL28RA
• IL-28Ra
• IL-28R-alpha
• Interferon lambda receptor 1
• interferon lambda, receptor 1
• interleukin 28 receptor A
• interleukin 28 receptor, alpha (interferon, lambda receptor)
• interleukin 28 receptor, alpha
• interleukin or cytokine receptor 2
• interleukin-28 receptor subunit alpha
• LICR2
• Likely interleukin or cytokine receptor 2

Background

IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IFNLR1
• Entrez:
  • 330496(Mouse)
  • 362628(Rat)