Reactivity | HuSpecies Glossary |
Applications | Flow |
Clone | 92101 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Alexa Fluor 594 |
Concentration | Please see the vial label for concentration. If unlisted please contact technical services. |
Conjugate | Catalog # | Availability | Size | Price |
---|---|---|---|---|
Alexa Fluor 350 | FAB6731U-100UG | |||
Alexa Fluor 405 | FAB6731V-100UG | |||
Alexa Fluor 488 | FAB6731G-100UG | |||
Alexa Fluor 647 | FAB6731R-100UG | |||
Alexa Fluor 700 | FAB6731N-100UG | |||
Alexa Fluor 750 | FAB6731S-100UG | |||
Fluorescein | FAB673F | |||
Phycoerythrin | FAB673P | |||
Unconjugated | MAB6731 | |||
Immunogen | Mouse myeloma cell line NS0-derived recombinant human IFN-gamma R1 Glu18-Gly245 Accession # P15260.1 |
Specificity | Detects human IFN-gamma R1 in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant mouse IFN‑ gamma R1, recombinant human (rh) IFN-gamma R2, or rhIL-10 R beta. |
Isotype | IgG1 |
Clonality | Monoclonal |
Host | Mouse |
Gene | IFNGR1 |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells. |
Storage | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
Buffer | Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide. |
Preservative | 0.09% Sodium Azide |
Concentration | Please see the vial label for concentration. If unlisted please contact technical services. |
The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 (IFN-gamma R alpha ) and IFN-gamma R2 (IFN-gamma R beta ). Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 499 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% amino acid sequence identity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids.
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 350 | FAB6731U | |
Alexa Fluor 405 | FAB6731V | |
Alexa Fluor 488 | FAB6731G | |
Alexa Fluor 594 | FAB6731T | |
Alexa Fluor 647 | FAB6731R | |
Alexa Fluor 700 | FAB6731N | |
Alexa Fluor 750 | FAB6731S | |
Fluorescein | FAB673F | |
Phycoerythrin | FAB673P |
Diseases for IFN-gamma R1/CD119 Antibody (FAB6731T)Discover more about diseases related to IFN-gamma R1/CD119 Antibody (FAB6731T).
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