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285-IF) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HeLa human cervical epithelial carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse Anti-Human IFN-gamma (2 ng/mL) is neutralized (green line) by increasing concentrations of Human IFN-gamma R1/CD119 Monoclonal Antibody (Catalog # MAB6731). The ND50 is typically 0.01-0.03 µg/mL." class="big_lightbox" target="_blank">
285-IF) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HeLa human cervical epithelial carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Human IFN-gamma (2 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IFN-gamma R1/CD119 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF673). The ND50 is typically 0.5-2 µg/mL." class="big_lightbox" target="_blank">
NL001) and counterstained with DAPI (blue). Specific staining was localized to plasma membrane. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." class="big_lightbox" target="_blank">
285-IF) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HeLa human cervical epithelial carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Human IFN-gamma (2 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human IFN-gamma R1/CD119 Mono-clonal Antibody (Catalog # MAB6732). The ND50 is typically 0.03-0.15 µg/mL." class="big_lightbox" target="_blank">
10067-IF) is immobilized at 3 µg/mL (100 µL/well), Recombinant Human IFN-gamma R1/CD119 His-tag Protein (Catalog # 11030-IR) binds with an ED50 of 0.0750-0.900 µg/mL." class="big_lightbox" target="_blank">
IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains.
![Neutralization IFN-gamma R1/CD119 Antibody (92101) [Unconjugated]](http://images.novusbio.com/images/antibody/IFN-gamma_R1_MAB6731_Block_Neutralize_2832.jpg)
![Neutralization IFN-gamma R1/CD119 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/IFN-gamma_R1_AF673_Block_Neutralize_1536.jpg)
![Neutralization IFN-gamma R1/CD119 Antibody (GIR208) [Unconjugated]](http://images.novusbio.com/images/antibody/IFN-gamma_R1_MAB6732_Block_Neutralize_2834.jpg)
![Sandwich ELISA IFN-gamma R1/CD119 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IFN-gamma-R1-CD119-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79602-img0001.jpg)
![N/A IFN-gamma R1/CD119 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IFNgamma_R1_DY1026_ELISA_1552.jpg)
![SEC-MALS IFN-gamma R1/CD119 [Unconjugated]](http://images.novusbio.com/fullsize/11030-ir_recombinant-human-ifn-gamma-r1-cd119-his-tag-protein-cf-sec-mals-2882025151335.jpg)
![Immunocytochemistry IFN-gamma R1/CD119 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/IFNgamma_R1_AF673_Immunocytochemistry__Immunofluorescence_17416.jpg)
![SDS-Page IFN-gamma R1/CD119 [Unconjugated]](http://images.novusbio.com/fullsize/11030-ir_recombinant-human-ifn-gamma-r1-cd119-his-tag-protein-cf-sds-page-2992022125217.jpg)
![Binding Activity IFN-gamma R1/CD119 [Unconjugated]](http://images.novusbio.com/images/11030-ir_recombinant-human-ifn-gamma-r1-cd119-his-tag-protein-cf-binding-activity-2911202262840.jpg)
