IFN-alpha/beta R2 Antibody [Phycoerythrin]

A20 mouse B cell lymphoma cell line was stained with Goat Anti-Mouse IFN-a/ beta R2 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB1083P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Phycoerythrin

IFN-alpha/beta R2 Antibody [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse IFN-alpha / beta R2
  Ser22-Ala239 (Lys160Asn)
  Accession # Q9D1R7
• Specificity: Detects mouse IFN‑ alpha / beta R2 in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant mouse (rm) IFN-gamma R2 and rmIL-20 R alpha is observed, 5% cross-reactivity with recombinant human (rh) IL-10 R beta , rmIFN-gamma RI, and rhIL-20 R beta is observed and less than 1% cross-reactivity with rhIFN-beta R alpha is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IFNAR2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha/beta R2 Antibody [Phycoerythrin]

• beta receptor10
• human interferon alpha
• human interferon alpha/beta receptor
• IFNABR
• IFN-alpha binding protein
• IFN-alpha/beta R2
• IFN-alpha/beta receptor 2
• IFN-alpha-REC
• IFNAR2
• IFN-aR2
• IFNARB
• IFNbR2
• IFN-bR2
• IFN-R
• IFN-R-2
• interferon (alpha, beta and omega) receptor 2
• Interferon alpha binding protein
• interferon alpha/beta receptor 2
• interferon-alpha/beta receptor beta chain
• Type I interferon receptor 2

Background

IFN-alpha / beta R2 belongs to the type II cytokine receptor family. It complexes with IFN-alpha / beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN-alpha / beta R2 can exist as a secreted soluble protein or as a type I membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-alpha/beta R2 Antibody (FAB1083P)(3)

Publications using FAB1083P

• HG Zhang, B Wang, Y Yang, X Liu, J Wang, N Xin, S Li, Y Miao, Q Wu, T Guo, Y Yuan, Y Zuo, X Chen, T Ren, C Dong, J Wang, H Ruan, M Sun, X Xu, H Zheng Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis Cell Research, 2022-07-12;0(0):. 2022-07-12 [PMID: 35821088] (Flow Cytometry, Mouse)
• KD Tuttle, KA Waugh, P Araya, R Minter, DJ Orlicky, M Ludwig, Z Andrysik, MA Burchill, BAJ Tamburini, C Sempeck, K Smith, R Granrath, D Tracy, J Baxter, JM Espinosa, KD Sullivan JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome Cell Rep, 2020-11-17;33(7):108407. 2020-11-17 [PMID: 33207208] (ICC, Rat)
• DA Banks, SE Ahlbrand, VK Hughitt, S Shah, KD Mayer-Barb, SN Vogel, NM El-Sayed, V Briken Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival J. Immunol., 2019-03-04;0(0):. 2019-03-04 [PMID: 30833347] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: IFNAR2
• Uniprot:
  • Q9D1R7()