Recombinant Human hydroxysteroid (17-beta) dehydrogenase 11 Protein

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Recombinant Human hydroxysteroid (17-beta) dehydrogenase 11 Protein [NBP1-50932]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.5 mg/ml

Order Details

Recombinant Human hydroxysteroid (17-beta) dehydrogenase 11 Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 20-285 of Human hydroxysteroid (17-beta) dehydrogenase 11

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MESFVKLFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
HSD17B11
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
31.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human hydroxysteroid (17-beta) dehydrogenase 11 Protein

  • 17betaHSD11
  • 17betaHSDXI
  • 17-beta-hydroxysteroid dehydrogenase 11
  • 17-beta-hydroxysteroid dehydrogenase type XI
  • 17-beta-hydroxysteroid dehydrogenase XI
  • 17bHSD11
  • CTCL-associated antigen HD-CL-03
  • dehydrogenase/reductase (SDR family) member 8
  • DHRS8
  • EC 1.1.1
  • EC 1.1.1.62
  • hydroxysteroid (17-beta) dehydrogenase 11
  • member 2,17-beta-HSD 11
  • PAN1BRETSDR2,17-BETA-HSD11
  • retSDR2
  • RetSDR2,17-BETA-HSDXI
  • SDR16C2,17BHSD11
  • T-cell lymphoma-associated antigen HD-CL-03,17-beta-HSD XI

Background

HSD17B11, also known as DHRS8 (dehydrogenase/reductase SDR family member 8), belongs to the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. It is widely expressed with highest levels found in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells. This protein converts androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone, suggesting it may participate in androgen metabolism during steroidogenesis. Recombinant human HSD17B11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol HSD17B11