Human IL-28A/IFN-lambda 2 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-28A/IFN-lambda 2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IFNL2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-28A/IFN-lambda 2 DuoSet ELISA, 15 Plate

• interleukin-28A
• IFN-lambda 2
• IL28A
• IL-28A
• interferon, lambda 2

Background

Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

Publications for IL-28A/IFN-lambda 2 (DY1587)(10)

Publications using DY1587

• A Rajamanick, NP Kumar, AN Pandiaraj, N Selvaraj, S Munisankar, RM Renji, V Venkatrama, M Murhekar, JWV Thangaraj, MS Kumar, CPG Kumar, T Bhatnagar, M Ponnaiah, R Sabarinath, V Saravanaku, S Babu Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals BMC immunology, 2022-10-26;23(1):51. 2022-10-26 [PMID: 36289478] (Human)
• Y Fukuda, T Homma, H Inoue, Y Goto, Y Sato, H Ikeda, C Onitsuka, H Sato, K Akimoto, T Ebato, H Suganuma, T Kawahara, H Mikuni, Y Uchida, S Suzuki, A Tanaka, H Sagara Serum IL-28A/IFN-lambda2 is linked to disease severity of COVID-19 Scientific Reports, 2022-03-31;12(1):5458. 2022-03-31 [PMID: 35361913] (Human)
• GR Kathamuthu, NP Kumar, K Moideen, D Baskaran, S Hissar, BM Shrinivasa, R Sridhar, S Babu Diminished circulating plasma and elevated lymph node culture supernatant levels of IL-10 family cytokines in tuberculous lymphadenitis Cytokine, 2018-06-02;0(0):. 2018-06-02 [PMID: 29871780] (Human)
• Suzuki T, Kawamura K, Li Q, Okamoto S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured. BMC Cancer, 2014-09-25;14(0):713. 2014-09-25 [PMID: 25255777] (Human)
• Dolganiuc A, Kodys K, Marshall C, Saha B, Zhang S, Bala S, Szabo G Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells. PLoS ONE, 2012-10-10;7(10):e44915. 2012-10-10 [PMID: 23071503] (Human)
• Bierne H, Travier L, Mahlakoiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M, Cossart P Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta. PLoS ONE, 2012-06-14;7(6):e39080. 2012-06-14 [PMID: 22720036] (Human)
• Hepatitis C virus NS3/4A protease blocks IL-28 production. Eur J Immunol, 2012-09-01;42(9):2374-82. 2012-09-01 [PMID: 22685015] (Human)
• Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, Nagata M, Shimada H, Kobayashi H, Tagawa M Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-lambda genes produced anti-tumour effects. Br. J. Cancer, 2011-09-27;105(9):1302-12. 2011-09-27 [PMID: 21952623] (Human)
• Pietila TE, Latvala S, Osterlund P, Julkunen I Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs. J. Leukoc. Biol., 2010-07-07;88(4):665-74. 2010-07-07 [PMID: 20610797] (Human)
• Stoltz M, Klingstrom J Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection. J. Virol., 2010-06-30;84(18):9140-8. 2010-06-30 [PMID: 20592090] (Human)

Bioinformatics

• Gene Symbol: IFNL2