HLA C Antibody (DT-9) [Alexa Fluor™ Plus 405]

• Reactivity: Hu
• Clone: DT-9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 405

HLA C Antibody (DT-9) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human HLA-C in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HLA C Antibody (DT-9) [Alexa Fluor™ Plus 405]

• C alpha chain
• D6S204
• FLJ27082
• HLA class I histocompatibility antigen, Cw-1 alpha chain
• HLAC
• HLA-C
• HLA-Cw
• HLA-JY3
• HLC-C
• human leukocyte antigen-C alpha chain
• leucocyte antigen C
• leucocyte antigen Cw
• leukocyte antigen-C alpha chain
• major histocompatibility antigen HLA-C
• major histocompatibility complex, class I, C
• MHC class I antigen Cw*1
• MHC class I antigen Cw*12
• MHC class I antigen Cw*14
• MHC class I antigen Cw*15
• MHC class I antigen Cw*16
• MHC class I antigen Cw*17
• MHC class I antigen Cw*2
• MHC class I antigen Cw*3
• MHC class I antigen Cw*4
• MHC class I antigen Cw*5
• MHC class I antigen Cw*6
• MHC class I antigen Cw*7
• MHC class I antigen Cw*8
• MHC class I antigen heavy chain HLA-C
• PSORS1

Background

HLA-A, B, and C are approximately 45 kDa transmembrane glycoproteins in the major histocompatibility complex 1 (MHC I) family. They contain three alpha domains in their extracellular regions. HLA molecules are expressed on nearly all nucleated cells in association with the 12 kDa beta 2-Microglobulin. This complex binds peptides derived from pathogenic cytosolic or extracellular proteins such as viral or microbial proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD8+ cytotoxic T cells. The activated cytotoxic T cell then kills the presenting cell. Mismatched MHC I alleles between a host and a donor lead to transplant rejection.

 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.