HLA C Products


HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq]


Entrez Human
Uniprot Human
Product By Gene ID 3107
Alternate Names
  • C alpha chain
  • D6S204
  • FLJ27082
  • HLA class I histocompatibility antigen, Cw-1 alpha chain
  • HLAC
  • HLA-Cw
  • HLA-JY3
  • HLC-C
  • human leukocyte antigen-C alpha chain
  • leucocyte antigen C
  • leucocyte antigen Cw
  • leukocyte antigen-C alpha chain
  • major histocompatibility antigen HLA-C
  • major histocompatibility complex, class I, C
  • MHC class I antigen Cw*1
  • MHC class I antigen Cw*12
  • MHC class I antigen Cw*14
  • MHC class I antigen Cw*15
  • MHC class I antigen Cw*16
  • MHC class I antigen Cw*17
  • MHC class I antigen Cw*2
  • MHC class I antigen Cw*3
  • MHC class I antigen Cw*4
  • MHC class I antigen Cw*5
  • MHC class I antigen Cw*6
  • MHC class I antigen Cw*7
  • MHC class I antigen Cw*8
  • MHC class I antigen heavy chain HLA-C
  • PSORS1

Research Areas for HLA C

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Adaptive Immunity

Bioinformatics Tool for HLA C

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