Histone Deacetylase 2/HDAC2 Antibody

Product Discontinued

Histone Deacetylase 2/HDAC2 Antibody Summary

• Immunogen: Peptide sequence around aa. 392~396 (E-D-S-G-D) derived from Human HDAC2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HDAC2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:200
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin
  • Western Blot 1:500-1:1000
• Application Notes: Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 27127168).

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Histone Deacetylase 2/HDAC2 Antibody

• EC 3.5.1.98
• HD2
• HDAC2
• Histone Deacetylase 2
• RPD3
• transcriptional regulator homolog RPD3
• YAF1
• YY1-associated factor 1

Background

HDAC-2 is a member of a large family of enzymes that alter gene expression by catalyzing the removal of acetyl groups from core histones. Originally isolated as a transcriptional co-repressor, HDAC-2 possesses extensive amino acid sequence homology to HDAC1 (the founding member and most extensively studied HDAC enzyme). HDAC-2 forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Histone Deacetylase 2/HDAC2 Antibody (NBP2-03980)(1)

Publication using NBP2-03980

• Baek MH, Park JY, Rhim CC et al. Immunohistochemical Characterization of Histone Deacetylase as a Potential Prognostic Marker and Therapeutic Target in Endometrial Stromal Sarcoma. Anticancer Res. 2016-05-01 [PMID: 27127168] (IHC-P, Human)

Bioinformatics

• Gene Symbol: HDAC2
• Uniprot:
  • NP_478057(Human)