HIC1 Antibody

Product Discontinued

HIC1 Antibody Summary

• Immunogen: Peptide with sequence HLEGYPCPHLAYGEP corresponding to internal region according to NP_001091672.1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_006488.2; NP_001091672.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: HIC1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
  • Western Blot 0.5 - 1 ug/ml
• Application Notes: WB: In transfected HEK293 transiently expressing human HIC1 a band of approx. 100 kDa is observed. This band is not observed in the mock-transfected HEK293. The same band is observed endogenously in the cell lines A549 and Jurkat. The calculated molecular size is 74.5 kDa band according to NP_006488.2.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for HIC1 Antibody

• hic-1
• hypermethylated in cancer 1
• ZBTB29hypermethylated in cancer 1 protein
• Zinc finger and BTB domain-containing protein 29
• ZNF901

Background

Transcriptional repressor. May act as a tumor suppressor. May be involved in development of head, face, limbsand ventral body wall

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HIC1 Antibody (NBP2-26158)(1)

Publication using NBP2-26158

• Yu J, Liu P, Cui X et al. Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions. Mol Cells 2011-07-01 [PMID: 21533545]

Bioinformatics

• Gene Symbol: HIC1
• Entrez:
  • 3090(Human)
  • 15248(Mouse)
  • 303310(Rat)