GSK-3 beta Antibody

Product Discontinued

GSK-3 beta Antibody Summary

• Immunogen: The immunogen for this antibody was a sequence from 21a.a. to 36a.a. from GSK3 beta(a 433a.a. long protein)
• Localization: Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
• Specificity: GSK3 beta
• Clonality: Polyclonal
• Host: Chicken
• Gene: GSK3B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: ELISA: Free peptide as test antigen (5 ug/ml). Affi-pure IgY as primary antibody and Rabbit anti-IgY HRP as 2nd antibody.
• Control:

  GSK-3 beta Overexpression Lysate

Reactivity Notes

This antibody is reactive against Human, mouse, rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for GSK-3 beta Antibody

• EC 2.7.11
• EC 2.7.11.26
• glycogen synthase kinase 3 beta
• glycogen synthase kinase-3 beta
• GSK3 beta
• GSK-3 beta
• GSK3B
• GSK3beta isoform

Background

Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control, and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GSK3B
• Entrez:
  • 2932(Human)
  • 56637(Mouse)
  • 84027(Rat)
• Uniprot:
  • P49841()