GSK-3 beta Products

Antibodies
GSK-3 beta [p Tyr279, p Tyr21 ...
GSK-3 beta [p Tyr279, p Tyr216] An...
Species: Hu, Mu, Rt, Ma
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Lysates
GSK-3 beta Overexpression Lys ...
GSK-3 beta Overexpression Lysate
NBL1-11362
Species: Hu
Applications: WB
Proteins
Recombinant Human Active GSK- ...
Recombinant Human Active GSK-3 bet...
2506-KS
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
GSK-3 beta Recombinant Protei ...
GSK-3 beta Recombinant Protein Ant...
NBP1-90359PEP
Species: Hu
Applications: AC

Description

Glycogen synthase kinase 3beta (GSK-3 beta) is a Serine/Threonine protein kinas involved in the insulin and wingless pathways (1-2). Originally identified as a regulator of glycogen synthase, it has been shown to regulate a diverse array of cellular functions. GSK-3 beta activity is down regulated by phosphorylation on Serine 9 by PKB, or activated by phosphorylation on Tyrosine 216. Once activated, the protein can phosphorylate p53, c-jun, heat shock factor-1 and cyclin D1 (3-4). It is also known to phosphorylate Tau in Allzheimer's disease. Additionally, increased GSK-3 beta protein levels are found in Alzheimer's disease brains.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.26
  • glycogen synthase kinase 3 beta
  • glycogen synthase kinase-3 beta
  • GSK-3 beta
  • GSK3beta isoform

Research Areas for GSK-3 beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway