GSK-3 beta Antibody (3A11) [HRP]

Product Discontinued

GSK-3 beta Antibody (3A11) [HRP] Summary

• Immunogen: The immunogen is a peptide made to the amino acid region Human GSK-3 beta
• Specificity: Human GSK-3 beta
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: GSK3B
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:1000-1:2000
  • Western Blot 1:100-1:2000
• Readout System:
  • NovaLume Plus Chemiluminescent Reagent LUM-555

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Stock solution in 50% Glycerol/50% PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A or G purified

Alternate Names for GSK-3 beta Antibody (3A11) [HRP]

• EC 2.7.11
• EC 2.7.11.26
• glycogen synthase kinase 3 beta
• glycogen synthase kinase-3 beta
• GSK3 beta
• GSK-3 beta
• GSK3B
• GSK3beta isoform

Background

Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 alpha and GSK-3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GSK3B