GRK7 Antibody (496831) [Alexa Fluor® 700]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 496831
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

GRK7 Antibody (496831) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human GRK7
  Lys342-Leu553
  Accession # Q8WTQ7
• Specificity: Detects human, mouse, and rat GRK7 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GRK7 Antibody (496831) [Alexa Fluor® 700]

• EC 2.7.11
• EC 2.7.11.16
• G protein-coupled receptor kinase 7
• GPRK7
• GPRK7G protein-coupled receptor kinase GRK7
• GRK7

Background

G protein-coupled receptor kinases (GRKs) are important modulators of G protein-coupled receptor (GPCR) signaling. Receptor phosphorylation by specific GRKs plays a key role in triggering rapid desensitization. The GRK family consists of 7 isoforms that share a central catalytic domain with homology to other serine/threonine kinases. The catalytic domain is flanked by an amino-terminal RGS domain of 183-188 amino acids and a carboxyl-terminus of variable length. GRK1 and GRK7 are members of the rhodopsin kinase or visual GRK subfamily. GRK7 is expressed in the cone outer segments of the retina and is able to phosphorylate rhodopsin in a light-dependent manner. In addition to its retina expression, GRK7 has been detected in other tissues, including brain, olfactory bulb, liver, lung and pancreas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.