GPR17 Antibody - BSA Free

Immunohistochemistry-Paraffin: GPR17 Antibody [NBP1-87531] - Staining in human cerebral cortex and liver tissues . Corresponding GPR17 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: GPR17 Antibody [NBP1-87531] - Staining of human liver shows no positivity in hepatocytes as expected.

Immunohistochemistry-Paraffin: GPR17 Antibody [NBP1-87531] - Staining of human cerebellum shows moderate positivity in oligodendrocytes.

Immunohistochemistry-Paraffin: GPR17 Antibody [NBP1-87531] - Staining of human cerebral cortex shows moderate positivity in oligodendrocytes.

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

GPR17 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit GPR17 Antibody - BSA Free (NBP1-87531) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: AEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
• Predicted Species: Mouse (92%), Rat (92%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GPR17
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  GPR17 Protein (NBP1-87531PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for GPR17 Antibody - BSA Free

• DKFZp686M18273
• G protein-coupled receptor 17
• GPR17
• G-protein coupled receptor 17
• P2Y-like Receptor
• R12
• UDP/CysLT Receptor
• uracil nucleotide/cysteinyl leukotriene receptor

Background

GPR17, a former orphan G-coupled protein is specifically activated by P2Y and CysLT endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In both rats and humans GPR17 expressed in the organs which suffer ischemic damage, like the brain, heart and kidneys. Studies by Ciana, et. al. have shown that inhibition of GPR17 reduces ischemic damage in a rat focal ischemia model. These results suggest GPR17 is the common molecular target mediating brain damage by nucleotides and CysLTs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GPR17