Species: Hu, Pm
Applications: ICC/IF, IHC, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
GPR17, a former orphan G-coupled protein is specifically activated by P2Y and CysLT endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In both rats and humans GPR17 expressed in the organs which suffer ischemic damage, like the brain, heart and kidneys. Studies by Ciana, et. al. have shown that inhibition of GPR17 reduces ischemic damage in a rat focal ischemia model. These results suggest GPR17 is the common molecular target mediating brain damage by nucleotides and CysLTs.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
2840 |
| Alternate Names |
- DKFZp686M18273
- G protein-coupled receptor 17
- G-protein coupled receptor 17
- P2Y-like receptor
- R12
- UDP/CysLT receptor
- uracil nucleotide/cysteinyl leukotriene receptor
|
Research Areas for GPR17
Find related products by research area and learn more about each of the different research areas below.
GPCRNeuroscience
