gamma-Synuclein Antibody

Western Blot: gamma-Synuclein Antibody [NBP1-04361] - The recombinant synuclein family and the extracts of HT-29 (colon adenocarcinoma) cells were resolved by SDS-PAGE, transferred to PVDF membrane and probed with polyclonal anti-human; -synuclein (1:1,000). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and the ECL detection system.

Product Discontinued

gamma-Synuclein Antibody Summary

• Immunogen: Recombinant human gamma-Synuclein purified from E. coli
• Specificity: This is specific for gamma-synuclein and does not cross-react with alpha- and beta-synuclein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SNCG
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:500-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 10% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for gamma-Synuclein Antibody

• BCSG1
• BCSG1PERSYN
• Breast cancer-specific gene 1 protein
• gamma-Synuclein
• persyn
• PRSN
• SNCG
• SRPRSN
• Synoretin
• synuclein, gamma (breast cancer-specific protein 1)
• Synuclein-gamma

Background

Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Although they are homologous, each synuclein is encoded by a different gene on chromosomes 4q21.3-q22. gamma-Synuclein (also called BCSG-1) is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SNCG
• Uniprot:
  • NP_003078.2(Human)