FZR1/CDH1 Antibody (DH01 (DCS-266))

Images

 
Western Blot: FZR1/CDH1 Antibody (DH01 (DCS-266)) [NBP2-22103] - Analysis of Cdh1 on LS174T Cells.
Immunocytochemistry/ Immunofluorescence: FZR1/CDH1 Antibody (DH01 (DCS-266)) [NBP2-22103] - Analysis of CD324/E Cadherin (green) showing staining in the in the cytoplasm, membrane of HT-29 cells (right) compared to a ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IP
Clone
DH01 (DCS-266)
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

FZR1/CDH1 Antibody (DH01 (DCS-266)) Summary

Immunogen
Recombinant human cdh1 protein
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FZR1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml
  • Immunoprecipitation 2 ug/mg

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4) and 0.2% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein G purified

Alternate Names for FZR1/CDH1 Antibody (DH01 (DCS-266))

  • anti-CDC20-like protein 1 antibody
  • anti-CDH1 antibody
  • anti-Cdh1/Hct1 homolog antibody
  • anti-Fizzy-related protein homolog antibody
  • anti-FYR antibody
  • anti-Fzr antibody
  • anti-FZR1 antibody
  • anti-hCDH1 antibody
  • CDC20C
  • CDH1
  • Cdh1/Hct1 homolog
  • CDH1CDC20-like 1b
  • fizzy/cell division cycle 20 related 1 (Drosophila)
  • FYR
  • Fzr
  • FZR2
  • FZRCDC20-like protein 1
  • hCDH1
  • HCDHFYR
  • KIAA1242
  • KIAA1242fizzy-related protein homolog

Background

FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FZR1
Uniprot