FXR2 Antibody (A42)

Product Discontinued

FXR2 Antibody (A42) Summary

• Immunogen: His6-FXR2s human fusion protein produced in a bacterial pET system
• Localization: Cytoplasmic
• Specificity: FXR2 (A42)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FXR2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: ELISA: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 92 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 10mM PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Concentration: 2.3 mg/ml
• Purity: Protein A or G purified

Alternate Names for FXR2 Antibody (A42)

• FMR1L2
• fragile X mental retardation syndrome-related protein 2
• fragile X mental retardation, autosomal homolog 2
• fragile X-mental retardation 1-like 2
• FXR2P

Background

FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. It may self-associate or interact with FMRP and FXR1. Fragile X syndrome is caused by the absence of the fragile X mental-retardation protein (FMRP). FMRP is the archetype of a class of cytoplasmic mRNA-binding proteins that includes the fragile X-related 1 and 2 proteins (FXR1 and FXR2). The fragile X-related proteins FXR1 and FXR2 contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FXR2
• Entrez:
  • 9513(Human)