FUBI/MNSF beta/FAU Antibody (861504) [Alexa Fluor™ Plus 405]

• Clone: 861504
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 405

FUBI/MNSF beta/FAU Antibody (861504) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human FUBI in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FUBI/MNSF beta/FAU Antibody (861504) [Alexa Fluor™ Plus 405]

• 40S Ribosomal Protein S30
• asr1
• FAU
• FAU1
• FAU-encoded ubiquitin-like protein
• FBR-MuSV-associated ubiquitously expressed
• Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
• Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed(fox derived)
• FLJ22986
• Fub1
• FUBI
• MNSFbeta
• monoclonal nonspecific suppressor factor beta
• ribosomal protein S30
• RPS30
• S30
• ubiquitin-like protein fubi and ribosomal protein S30
• ubiquitin-like-S30 fusion protein

Background

The ubiquitin-like protein FUBI/ MNSF beta (Monoclonal Nonspecific Suppressor Factor Beta) is encoded by the FAU gene, and is translated as a pro-form consisting of FUBI fused to the ribosomal S30 protein. S30 is cleaved in a post-translational reaction, releasing the mature 74 amino acid FUBI/MNSF beta protein. FUBI has a
C-terminal gly-gly motif common to many ubiquitin-like proteins.  FUBI/ MNSF beta conjugation to Bcl-G has been shown to regulate the ERK1/2-MAPK cascade in macrophage cell lines, and may be implicated in TLR4-mediated signal transduction. Conjugation to endophilin II regulates dectin-1-mediated phagocytosis and inflammatory responses, and may be implicated in TLR2 signaling pathway.

1. Rossman,T.G. et al. (2003) Oncogene 22:1817.
2. Nakamura, M. & Omura, S. (2008) Biosci. Biotech. Biochem. 72:1915.
3. Nakamura, M. & Yamaguchi, S. (2006) J. Biol. Chem. 281:16861.
4. Nakamura, M & Watanabe, N. (2010) Biochem, Biophys. Res. Comm. 15:275.
5. Nakamura, M. et al. (2012) Mol. Cell Biochem. 364:39.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.