FKBP25 Antibody [Alexa Fluor® 405]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 405

FKBP25 Antibody [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human FKBP25
  Ala2-Asp224
  Accession # Q00688
• Specificity: Detects endogenous human, mouse, and rat FKBP25 in Western blots. In Western blots, this antibody does not cross-react with recombinant human FKBP12, FKBP38, FKBP51, or FKBP52.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP25 Antibody [Alexa Fluor® 405]

• EC 5.2.1.8,25 kDa FK506-binding protein
• FK506 binding protein 3, 25kDa
• FK506-binding protein 3 (25kD)
• FK506-binding protein 3
• FKBP25
• FKBP25,25 kDa FKBP
• FKBP3
• FKBP-3
• Immunophilin FKBP25
• peptidyl-prolyl cis-trans isomerase FKBP3
• PPIase FKBP3
• PPIase
• rapamycin binding protein
• Rapamycin-selective 25 kDa immunophilin
• rotamase
• T-cell

Background

FK506 binding protein, 25 kilodalton molecular weight (FKBP25), also called FKBP3, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans‑proline residues critical for proper folding of proteins. The macrolide immunosuppressant rapamycin is a potent inhibitor of FKBP25. FKBP25 is localized in the nucleus, where it alters the activity of histone deacetylases and transcription factors. FKBP25 is found in many tissues, including the brain, thymus, and spleen.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.