Ferroportin/SLC40A1 Antibody (8G10NB) Summary
Partial recombinant human Ferroportin protein (between amino acids 150-350) [UniProt Q9NP59]
Protein G purified
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- Western Blot 2-4 ug/ml
- Flow Cytometry
- Immunohistochemistry 5 ug/ml
- Immunohistochemistry-Paraffin 5 ug/ml
- Flow (Cell Surface) 25 ug/ml
- Flow (Intracellular)
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Protein G purified
Alternate Names for Ferroportin/SLC40A1 Antibody (8G10NB)
- FPN1IREG1ferroportin 1
- Iron-regulated transporter 1
- member 3
- putative ferroportin 1 variant IIIB
- SLC11A3iron regulated gene 1
- solute carrier family 11 (proton-coupled divalent metal ion transporters)
- solute carrier family 40 (iron-regulated transporter), member 1
- solute carrier family 40 member 1
Ferroportin 1 (FPN1 or SLC40A1) is an iron-regulated transporter (highly expressed in placenta, intestine, muscle, spleen etc.) that play key role in intestinal iron absorption as well as cellular iron release, and mediates iron efflux in the presence of ferroxidases hephaestin (HP) and/or ceruloplasmin (CP). FPN1 is implicated in the iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. FPN1 can be regulated transcriptionally, post-transcriptionally, through mRNA stability and post-translationally through protein turnover and its regulation is critical for iron homeostasis because alterations in the same may lead to either iron deficiency or iron overload. FPN1 transports iron in ferrous form whereas plasma transferrin only binds iron's ferric form, and ferroxidases are key players in oxidizing iron transported by FPN1, and without the activity of ferroxidases, FPN1 is internalized followed by degradation. While other cell types in the body utilize the circulating or GPI-linked multicopper ferroxidase CP for FPN1, intestinal cells utilize a membrane-bound HP, a paralog of CP that also show interaction with FPN1. Defects in FPN1 have been linked to hemochromatosis type 4 (HFE4), an autosomal dominant iron-loading disorder.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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