Ferroportin/SLC40A1 Antibody (8G10NB)

Images

 
Western Blot: Ferroportin/SLC40A1 Antibody (8G10NB) [NBP2-45356] - Western blot analysis of Ferroportin/SLC40A1 in (A) recombinant human Ferroportin protein at 0.5 ug/ml and (B) NCCIT lysate at 2 ug/ml.
Immunohistochemistry-Paraffin: Ferroportin/SLC40A1 Antibody (8G10NB) [NBP2-45356] - IHC analysis of a formalin fixed paraffin embedded human spleen section using mouse monoclonal Ferroportin/SLC40A1 antibody at 5 ug/ml ...read more
Flow (Intracellular): Ferroportin/SLC40A1 Antibody (8G10NB) [NBP2-45356] - An intracellular stain was performed on HepG2 cells with Ferroportin/SLC40A1 antibody (8G10NB) NBP2-45356AF647 (blue) and a matched isotype ...read more
Flow Cytometry: Ferroportin/SLC40A1 Antibody (8G10NB) [NBP2-45356] - Detection of SLC40A1/Ferroportin 1 in HEK293 Human Cell Line Transfected with Human SLC40A1/Ferroportin 1 by Flow Cytometry. HEK293 human embryonic ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, Flow-CS, Flow-IC, IHC, IHC-P
Clone
8G10NB
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Ferroportin/SLC40A1 Antibody (8G10NB) Summary

Immunogen
Partial recombinant human Ferroportin protein (between amino acids 150-350) [UniProt Q9NP59]
Localization
Membrane, Cytoplasm
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SLC40A1
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 2-4 ug/ml
  • Flow Cytometry
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Flow (Cell Surface) 25 ug/ml
  • Flow (Intracellular)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Ferroportin/SLC40A1 Antibody (8G10NB)

  • Ferroportin
  • Ferroportin-1
  • FPN1
  • FPN1IREG1ferroportin 1
  • HFE4
  • HFE4ferroportin-1
  • IREG1
  • Iron-regulated transporter 1
  • member 3
  • MST079
  • MTP1
  • putative ferroportin 1 variant IIIB
  • SLC11A3
  • SLC11A3iron regulated gene 1
  • SLC40A1
  • solute carrier family 11 (proton-coupled divalent metal ion transporters)
  • solute carrier family 40 (iron-regulated transporter), member 1
  • solute carrier family 40 member 1

Background

Ferroportin 1 (FPN1 or SLC40A1) is an iron-regulated transporter (highly expressed in placenta, intestine, muscle, spleen etc.) that play key role in intestinal iron absorption as well as cellular iron release, and mediates iron efflux in the presence of ferroxidases hephaestin (HP) and/or ceruloplasmin (CP). FPN1 is implicated in the iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. FPN1 can be regulated transcriptionally, post-transcriptionally, through mRNA stability and post-translationally through protein turnover and its regulation is critical for iron homeostasis because alterations in the same may lead to either iron deficiency or iron overload. FPN1 transports iron in ferrous form whereas plasma transferrin only binds iron's ferric form, and ferroxidases are key players in oxidizing iron transported by FPN1, and without the activity of ferroxidases, FPN1 is internalized followed by degradation. While other cell types in the body utilize the circulating or GPI-linked multicopper ferroxidase CP for FPN1, intestinal cells utilize a membrane-bound HP, a paralog of CP that also show interaction with FPN1. Defects in FPN1 have been linked to hemochromatosis type 4 (HFE4), an autosomal dominant iron-loading disorder.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-45356AF405
Alexa Fluor 488 Labeled NBP2-45356AF488
Alexa Fluor 647 Labeled NBP2-45356AF647
Alexa Fluor 700 Labeled NBP2-45356AF700
Allophycocyanin Labeled NBP2-45356APC
Biotin Labeled NBP2-45356B
DyLight 350 Labeled NBP2-45356UV
DyLight 405 Labeled NBP2-45356V
DyLight 488 Labeled NBP2-45356G
DyLight 550 Labeled NBP2-45356R
DyLight 650 Labeled NBP2-45356C
DyLight 680 Labeled NBP2-45356FR
DyLight 755 Labeled NBP2-45356IR
HRP Labeled NBP2-45356H
PerCP Labeled NBP2-45356PCP
Phycoerythrin Labeled NBP2-45356PE

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Bioinformatics

Gene Symbol SLC40A1
Entrez
Uniprot