Ferroportin/SLC40A1 Products

Antibodies
Lysates
Ferroportin/SLC40A1 293T Cell ...
Ferroportin/SLC40A1 293T Cell Tran...
H00030061-T02
Species: Hu
Applications: WB
Proteins
Ferroportin/SLC40A1 Antibody ...
Ferroportin/SLC40A1 Antibody Block...
NBP1-21502PEP
Species: Hu
Applications: AC
Ferroportin/SLC40A1 Recombina ...
Ferroportin/SLC40A1 Recombinant Pr...
NBP2-49454PEP
Species: Hu
Applications: AC

Description

Ferroportin is a 12-transmembrane domain protein, belonging to the major facilitator superfamily of transporters of small molecules, that is localized to the plasma membrane. Human Ferroportin has a theoretical molecular weight of 62.5 kDa. Ferroportin (FPN1 or SLC40A1) functions as an iron-regulated transporter (highly expressed in placenta, intestine, muscle, spleen, macrophages etc.) and is the receptor for the iron-regulatory hormone, hepcidin. In iron metabolism, FPN1 plays a key role in intestinal iron absorption as well as cellular iron release and mediates iron absorption in the presence of ferroxidases, hephaestin (HP) and/or ceruloplasmin (CP). FPN1 is implicated in iron export from duodenal epithelial cells and in the transfer of iron between maternal and fetal circulation. FPN1 transports iron in the ferrous form whereas plasma transferrin only binds iron's ferric form. Ferroxidases are key players in oxidizing iron transported by FPN1 and without the activity of ferroxidases, FPN1 is internalized followed by degradation. While other cell types utilize the circulating or GPI-linked multicopper ferroxidase CP for FPN1, intestinal cells utilize a membrane-bound HP, a paralog of CP that also show interaction with FPN1 (1).

FPN1 regulation is dependent on the cell type and involves transcriptional, posttranscriptional, and posttranslational mechanisms including hepcidin-mediated endocytosis and proteolysis. Hepcidin controls the concentration of FPN1 in the membrane, with hepcidin deficiency resulting in iron overload (high iron) and hepcidin excess leading to iron restriction and anemia (2). Ferroportin disease or hemochromatosis type 4 (HFE4) is associated with distinct FPN1 variants with either reduced FPN1 cell surface expression/iron export capacity or hepcidin resistance and iron overload (3, 4).

References

1. De Domenico I, Ward DM, Kaplan J. (2011) Hepcidin and ferroportin: the new players in iron metabolism. Semin Liver Dis. 31(3):272-9. PMID: 21901657

2. Drakesmith H, Nemeth E, Ganz T. (2015) Ironing out Ferroportin. Cell Metab. 22(5):777-87. PMID: 26437604

3. Pietrangelo A. (2017) Ferroportin disease: pathogenesis, diagnosis and treatment. Haematologica. 102(12):1972-1984. PMID: 29101207

4. Vlasveld LT, Janssen R, Bardou-Jacquet E, Venselaar H, Hamdi-Roze H, Drakesmith H, Swinkels DW. (2019) Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features. Pharmaceuticals (Basel). 12(3). pii: E132. PMID: 31505869

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 30061
Alternate Names
  • MSTP079
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
  • IREG1
  • HFE4
  • SLC11A3
  • iron regulated gene 1
  • FPN1
  • Ferroportin-1
  • Iron-regulated transporter 1
  • solute carrier family 40 member 1
  • member 3
  • solute carrier family 11 (proton-coupled divalent metal ion transporters)
  • putative ferroportin 1 variant IIIB
  • MTP1
  • SLC11A3iron regulated gene 1
  • HFE4ferroportin-1
  • FPN1IREG1ferroportin 1
  • MST079
  • solute carrier family 40 (iron-regulated transporter), member 1

Research Areas for Ferroportin/SLC40A1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction

PTMs for Ferroportin/SLC40A1

Learn more about PTMs related to Ferroportin/SLC40A1.

Cleavage

Bioinformatics Tool for Ferroportin/SLC40A1

Discover related pathways, diseases and genes to Ferroportin/SLC40A1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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