FDPS Antibody

Western Blot: FDPS Antibody [H00002224-B01P] - Analysis of FDPS expression in transfected 293T cell line by FDPS polyclonal antibody. Lane 1: FDPS transfected lysate(46.09 KDa). Lane 2: Non-transfected lysate.

Western Blot: FDPS Antibody [H00002224-B01P] - FDPS MaxPab polyclonal antibody. Western Blot analysis of FDPS expression in HepG2.

Western Blot: FDPS Antibody [H00002224-B01P] - FDPS MaxPab polyclonal antibody. Western Blot analysis of FDPS expression in human placenta.

Product Discontinued

FDPS Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: FDPS (NP_001995.1, 1 a.a. - 419 a.a.) full-length human protein. MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
• Specificity: FDPS - farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: FDPS
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for FDPS Antibody

• 6E)-farnesyl diphosphate synthase
• Dimethylallyltranstransferase
• EC 2.5.1.1
• EC 2.5.1.10
• farnesyl diphosphate synthaseFPP synthetase
• farnesyl pyrophosphate synthase
• farnesyl pyrophosphate synthetase, dimethylallyltranstransferase
• FDPS
• FPP synthase
• FPPS
• FPSgeranyltranstransferase
• Geranyltranstransferase
• KIAA1293

Background

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FDPS
• Entrez:
  • 2224(Human)
• Uniprot:
  • NP_001995.1(Human)