FCRL6/FcRH6 Antibody (672505) [Allophycocyanin]

• Applications: Flow
• Clone: 672505
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

FCRL6/FcRH6 Antibody (672505) [Allophycocyanin] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human FCRL6/FcRH6
  Lys16-Leu312
  Accession # Q6DN72
• Specificity: Detects human FCRL6/FcRH6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) FCRL1, rhFCRL2, rhFCRL3, rhFCRL4, rhFCRL5, rhFcRN, or rhFCRLB/FCRY is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FCRL6
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

FCRL6 (Fc receptor-like protein 6; also FcRH6 and IFGP6) is a 66 kDa member of the Ig Superfamily.  It is found on CD56dim CD16⁺ NK cells, CD56⁺ CD3⁺ NKT cells, gd T cells, and effector plus effector-memory CD8⁺ T cells.  FCRL6 is not a receptor for immunoglobulin.  It does, however, bind to isoforms of HLA-DR that are expressed on APCs.  Given that FCRL6 contains a cytoplasmic ITIM, FCRL6 may function as an inhibitory receptor for MHC Class II.  Mature human FCRL6 is a 415 amino acid (aa) type I transmembrane protein.  It contains a 288 aa extracellular region (aa 20-307) that shows three C2-type Ig-like domains (aa 20-293), and a 106 aa cytoplasmic domain.  There are multiple potential splice variants.  One shows a deletion of aa 105-200 accompanied by a 13 aa substitution for aa 394-434; a second possesses a 15 aa substitution for aa 383-434; and a third shows an alternative start site seven aa upstream of the standard site accompanied by a 13 aa substitution for aa 394-434.  Over aa 16-312, human FCRL6 shares only 33% aa identity with the mouse counterpart to FCRL6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FCRL6