ErbB3/Her3 Antibody (SGP1)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IHC, IP, CyTOF-ready
Clone
SGP1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ErbB3/Her3 Antibody (SGP1) Summary

Immunogen
c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography
Epitope
Extracellular domain.
Localization
Cell Membrane (long form) and secreted (short form).
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ERBB3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • CyTOF-ready
Application Notes
This antibody is Cytof ready.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A or G purified

Alternate Names for ErbB3/Her3 Antibody (SGP1)

  • c-erbB3
  • EC 2.7.10
  • EC 2.7.10.1
  • ErbB3
  • ErbB-3
  • erbB3-S
  • HER3
  • HER3c-erbB-3
  • LCCS2
  • lethal congenital contracture syndrome 2
  • MDA-BF-1
  • MGC88033
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • Proto-oncogene-like protein c-ErbB-3
  • receptor tyrosine-protein kinase erbB-3
  • Tyrosine kinase-type cell surface receptor HER3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Background

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for ErbB3/Her3 Antibody (NB100-2692) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB100-2692AF350
Alexa Fluor 405 NB100-2692AF405
Alexa Fluor 488 NB100-2692AF488
Alexa Fluor 532 NB100-2692AF532
Alexa Fluor 594 NB100-2692AF594
Alexa Fluor 647 NB100-2692AF647
Alexa Fluor 700 NB100-2692AF700
Alexa Fluor 750 NB100-2692AF750
Allophycocyanin NB100-2692APC
Allophycocyanin/Cy7 NB100-2692APCCY7
DyLight 350 NB100-2692UV
DyLight 405 NB100-2692V
DyLight 488 NB100-2692G
DyLight 550 NB100-2692R
DyLight 594 NB100-2692DL594
DyLight 650 NB100-2692C
DyLight 680 NB100-2692FR
DyLight 755 NB100-2692IR
FITC NB100-2692F
Janelia Fluor 549 NB100-2692JF549
Janelia Fluor 646 NB100-2692JF646
PE NB100-2692PE
PE/Atto594 NB100-2692PEATT594
PE/Cy5.5 NB100-2692PECY55
PE/Cy7 NB100-2692PECY7
PerCP NB100-2692PCP

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Bioinformatics Tool for ErbB3/Her3 Antibody (NB100-2692)

Discover related pathways, diseases and genes to ErbB3/Her3 Antibody (NB100-2692). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on ErbB3/Her3

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Contact Information

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Bioinformatics

Gene Symbol ERBB3
Entrez