ErbB3/Her3 Products

Antibodies
ErbB3/Her3 Antibody
ErbB3/Her3 Antibody
AF234
Species: Hu
Applications: WB, Flow, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ErbB3/Her3 Antibody
ErbB3/Her3 Antibody
NBP2-32253
Species: Hu, Bovine, Equine, Feline, Guinea Pig, Primate, Mouse, Rabbit, Rat, Bat, Chinese Hamster, Squirrel, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
ELISA Kits
ErbB3/Her3 ELISA Kit [Biotin] ...
ErbB3/Her3 ELISA Kit [Biotin]
KA1710
Species: Hu
Applications: ELISA
Lysates
ErbB3/Her3 Overexpression Lys ...
ErbB3/Her3 Overexpression Lysate (...
H00002065-T01
Species: Hu
Applications: WB
ErbB3/Her3 Overexpression Lys ...
ErbB3/Her3 Overexpression Lysate (...
NBP2-04209
Applications: WB
ErbB3/Her3 Overexpression Lys ...
ErbB3/Her3 Overexpression Lysate (...
NBP2-09102
Applications: WB
Proteins
ErbB3/Her3 Recombinant Protei ...
ErbB3/Her3 Recombinant Protein Ant...
NBP2-33289PEP
Species: Hu
Applications: AC
ErbB3/Her3 Recombinant Protei ...
ErbB3/Her3 Recombinant Protein
NBP2-52128
Species: Hu
Applications: PAGE
ErbB3/Her3 Recombinant Protei ...
ErbB3/Her3 Recombinant Protein
NBP2-52302
Species: Mu
Applications: PAGE
RNAi
ErbB3/Her3 RNAi
ErbB3/Her3 RNAi
H00002065-R08
Species: Hu
ErbB3/Her3 RNAi
ErbB3/Her3 RNAi
H00002065-R07
Species: Hu

Description

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 2065
Alternate Names
  • EC 2.7.10
  • MDA-BF-1
  • receptor tyrosine-protein kinase erbB-3
  • ErbB-3
  • p85-sErbB3
  • lethal congenital contracture syndrome 2
  • p45-sErbB3
  • LCCS2
  • p180-ErbB3
  • EC 2.7.10.1
  • erbB3-S
  • Tyrosine kinase-type cell surface receptor HER3
  • c-erbB3
  • Proto-oncogene-like protein c-ErbB-3
  • HER3c-erbB-3
  • MGC88033
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Research Areas for ErbB3/Her3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Protein Kinase
Tumor Suppressors

Bioinformatics Tool for ErbB3/Her3

Discover related pathways, diseases and genes to ErbB3/Her3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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