ErbB3/Her3 Products

Description

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Bioinformatics

Entrez	13867 Mouse 2065 Human 29496 Rat
Uniprot	AAH02706 Human AAH02706.1 Human NP_001005915 Human NP_001973 Human NP_001973.2 Human P21860 Human
Product By Gene ID	2065
Alternate Names	c-erbB3 EC 2.7.10 EC 2.7.10.1 ErbB-3 erbB3-S HER3c-erbB-3 LCCS2 lethal congenital contracture syndrome 2 MDA-BF-1 MGC88033 p180-ErbB3 p45-sErbB3 p85-sErbB3 Proto-oncogene-like protein c-ErbB-3 receptor tyrosine-protein kinase erbB-3 Tyrosine kinase-type cell surface receptor HER3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Research Areas for ErbB3/Her3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Protein Kinase
Tumor Suppressors

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