Dynorphin Antibody (NOC.1)

Product Discontinued

Dynorphin Antibody (NOC.1) Summary

• Immunogen: Synthetic peptide corresponding to part of the native molecule conjugated to Bovine Serum Albumin.
• Localization: Secreted
• Specificity: This product recognises bioth Met5- and Leu5-enkephalin, secreted peptides which mimic the effect of opiate drugs. This antibody recognises well established enkephalin immunoreactive sites, but does not bind to areas known to contain beta-endorphin or dynorphin in IHC.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: PDYN
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Radioimmunoassay 1:100-1:2000
• Application Notes: It has also been reported in the literature to be useful in Radioimmunoassays and Immunocytochemistry/immunoflourescence as (PMID: 6086744)

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tissue culture supernatant
• Preservative: 0.05% Thimerosal
• Purity: Tissue culture supernatant

Alternate Names for Dynorphin Antibody (NOC.1)

• ADCA
• Beta-neoendorphin-dynorphin
• leu-enkephalin
• leumorphin
• MGC26418
• PENKB
• preprodynorphin
• preproenkephalin B
• prodynorphin
• proenkephalin-B
• rimorphin
• SCA23
• spinocerebellar ataxia 23

Background

Enkephalin and enkephalin-like peptides have been detected in many animal species. In mammals these opioid pentapeptides are cleaved from a common precursor molecule which is expressed in a number of cell types, including neurons and endocrine cells associated with the sympathetic nervous system where they are often co-stored with catecholamines. They are known to be endogenous ligands for Sopioid receptors and are known to mediate analgesia at the spinal level.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: PDYN
• Entrez:
  • 5179(Human)
  • 18610(Mouse)
  • 29190(Rat)
• Uniprot:
  • P01210(Human)