DYNC1H1 Antibody [DyLight 680]

Product Discontinued

DYNC1H1 Antibody [DyLight 680] Summary

• Immunogen: dynein, cytoplasmic 1, heavy chain 1. (Uniprot# Q14204)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DYNC1H1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DYNC1H1 Antibody [DyLight 680]

• cytoplasmic dynein 1 heavy chain 1
• Cytoplasmic dynein heavy chain 1
• DHC1a
• DHC1Dynein heavy chain, cytosolic
• DKFZp686P2245
• Dnchc1
• DNCLDNCH1
• DNECLDYHC
• dynein, cytoplasmic 1, heavy chain 1
• dynein, cytoplasmic, heavy polypeptide 1
• HL-3
• KIAA0325
• p22

Background

The DYNC1H1 gene encodes a cytoplasmic dynein 1 heavy chain 1 protein that is 4,646 amino acids long at 532 kDA. Dyneines function as molecular motors that contain ATPase activity. Defects in DYNC1H1 cause Charcot-Marie-Tooth Disease type 2O (CMT2O), mental retardation autosomal dominant type 13 (MRD13), as well as spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). DYNC1H1 has also been investigated by researchers in myeloma, neuropathy, ciliary dyskinesia, lateral sclerosis, intellectual disabilities, lissencephaly, schizophrenia, malaria, and neurodegeneration. DYNC1H1 participates in centrosome maturation, adaptive immune system, cytoplasmic microtubules, cell cycle spindle assembly and chromosome separation, as well as phagosome and vasopressin-regulated water reabsorption. DYNC1H1 interacts with genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H43.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DYNC1H1