DUSP8 Antibody

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Western Blot: DUSP8 Antibody [NB100-886] - Staining (2ug/ml) of Human Heart lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

DUSP8 Antibody Summary

Immunogen
Peptide with sequence AGDRLPRKVMDAK-C corresponding to N-Terminus according to NP_004411.2.
Specificity
This antibody is also expected to recognise the hypothetical human protein similar to dual specificity phosphatase 8 (XM_114902), which is virtually identical.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
DUSP8
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:4000
Application Notes
WB: Approx. 60-65 kDa band bands observed in human heart lysate.
Publications
Read Publication using NB100-886.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DUSP8 Antibody

  • C11orf81
  • chromosome 11 open reading frame 81
  • dual specificity phosphatase 8
  • Dual specificity protein phosphatase hVH-5
  • EC 3.1.3.16
  • EC 3.1.3.48
  • FLJ42476
  • FLJ42958
  • HVH8
  • serine/threonine specific protein phosphatase
  • vaccinia virus homolog
  • VH5

Background

DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for DUSP8 Antibody (NB100-886)(1)

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Bioinformatics

Gene Symbol DUSP8
Entrez
Uniprot