DUSP8 Products

Antibodies
DUSP8 Antibody
DUSP8 Antibody
NB100-56410
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
DUSP8 Antibody
DUSP8 Antibody
NBP1-88385
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
DUSP8 Antibody
DUSP8 Antibody
NBP1-31169
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
DUSP8 Overexpression Lysate ( ...
DUSP8 Overexpression Lysate (Native)
NBP2-07874
Applications: WB
Proteins
Recombinant Human DUSP8 Prote ...
Recombinant Human DUSP8 Protein
H00001850-Q01
Species: Hu
Applications: WB, ELISA, PA
DUSP8 Recombinant Protein Ant ...
DUSP8 Recombinant Protein Antigen
NBP1-88385PEP
Species: Hu
Applications: AC
RNAi
DUSP8 RNAi
DUSP8 RNAi
H00001850-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 1850
Alternate Names
  • VH5
  • chromosome 11 open reading frame 81
  • EC 3.1.3.48
  • HVH8
  • EC 3.1.3.16
  • C11orf81
  • serine/threonine specific protein phosphatase
  • Dual specificity protein phosphatase hVH-5
  • vaccinia virus homolog
  • FLJ42958
  • FLJ42476
  • dual specificity phosphatase 8

Research Areas for DUSP8

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Signal Transduction

PTMs for DUSP8

Learn more about PTMs related to DUSP8.

Phosphorylation
Dephosphorylation
Methylation

Bioinformatics Tool for DUSP8

Discover related pathways, diseases and genes to DUSP8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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