DUSP10 Antibody

Product Discontinued

DUSP10 Antibody Summary

• Immunogen: DUSP10 (AAH20608, 1 a.a. ~ 141 a.a) full length recombinant protein with GST tag.MQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV
• Specificity: DUSP10 - dual specificity phosphatase 10
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: DUSP10
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DUSP10 Antibody

• dual specificity phosphatase 10
• dual specificity phosphatase MKP-5
• EC 3.1.3.16
• EC 3.1.3.48
• MAP kinase phosphatase 5
• Mitogen-activated protein kinase phosphatase 5
• MKP-5dual specificity protein phosphatase 10
• MKP5serine/threonine specific protein phosphatase

Background

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DUSP10 Antibody (H00011221-A01)(1)

Publication using H00011221-A01

• Wang H, Daouti S, Li WH et al. Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-RafV600E Mutation. Cancer Res. 2011-06-24 [PMID: 21705440]

Bioinformatics

• Gene Symbol: DUSP10
• Entrez:
  • 11221(Human)
• OMIM:
  • 608867(Human)
• Uniprot:
  • AAH20608(Human)