DUSP10 Products

Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Bioinformatics

Entrez	11221 Human
Uniprot	AAH20608 Human D3DTB4 Human NM_007207 Human NM_144728 Human NP_009138 Human NP_009138.1 Human NP_653330 Human Q9Y6W6 Human
Product By Gene ID	11221
Alternate Names	dual specificity phosphatase 10 dual specificity phosphatase MKP-5 EC 3.1.3.16 EC 3.1.3.48 MAP kinase phosphatase 5 Mitogen-activated protein kinase phosphatase 5 MKP-5dual specificity protein phosphatase 10 MKP5serine/threonine specific protein phosphatase

Research Areas for DUSP10

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Signal Transduction