DRAK1 Antibody [Alexa Fluor® 488]

• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

DRAK1 Antibody [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human DRAK1
  Ala115-Glu313
  Accession # Q9UEE5
• Specificity: Detects human DRAK1 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross‑reactivity with recombinant human DRAK2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1; also STK17A) is a 55 kDa member of the DAP kinase subfamily, CAMK Ser/Thr protein kinase family of enzymes. It is expressed in osteoclasts, resides in the nucleus and initiates apoptosis. Human DRAK1 is 414 amino acids (aa) in length. It contains an N‑terminal polyPro segment (aa 33‑37) followed by a Ser/Thr kinase domain (aa 64‑321) with a catalytic loop (aa 184‑193). Apoptosis apparently requires an intact kinase domain. No rodent DRAK1 has been reported. Over aa 115‑313, human DRAK1 is 95% aa identical to canine DRAK1, and 65% aa identical to human DRAK2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.