DMP-1 Antibody

Images

 
Western Blot: DMP-1 Antibody [NBP1-45525] - Odonto/osteogenic differentiation in canonical NF-kB-inhibited SCAPs. The odonto/osteogenic protein levels of SCAPs in control, inhibitor, MM, and inhibitor + MM groups were ...read more
Western Blot: DMP-1 Antibody [NBP1-45525] - Analysis of DMP-1 in rat kidney tissue lysate.
Western Blot: DMP-1 Antibody [NBP1-45525] - Odonto/osteogenic differentiation in canonical NF-kB-activated SCAPs. Western blot analyses for the odonto/osteogenic proteins (BSP, OCN, RUNX2, OSX, DSP, OPN, DSP, and DMP-1) ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

DMP-1 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues surrounding amino acids 21 of rat DMP-1 (EDL99499).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DMP1
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 30755596).
Publications
Read Publications using
NBP1-45525 in the following applications:

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2), 30% glycerol, 0.5% BSA
Preservative
0.01% Thimerosal
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for DMP-1 Antibody

  • ARHP
  • ARHR
  • dentin matrix acidic phosphoprotein 1
  • dentin matrix acidic phosphoprotein
  • Dentin matrix protein 1
  • DMP1
  • DMP-1

Background

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for DMP-1 Antibody (NBP1-45525)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.


Filter By Application
ICC/IF
(1)
WB
(4)
All Applications
Filter By Species
Human
(6)
All Species
Showing Publications 1 - 6 of 6.
Publications using NBP1-45525 Applications Species
Miyagawa K, Ohata Y, Delgado-Calle J et al. Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo JCI Insight Feb 20 2020 [PMID: 32078587] (Human) Human
Li Z, Yan M, Yu Y et al. LncRNA H19 promotes the committed differentiation of stem cells from apical papilla via miR-141/SPAG9 pathway Cell Death Dis Feb 12 2019 [PMID: 30755596] (ICC/IF, Human) ICC/IF Human
Wang Y, Lu Y, Li Z et al. Oestrogen receptor a regulates the odonto/osteogenic differentiation of stem cells from apical papilla via ERK and JNK MAPK pathways Cell Prolif. Aug 2 2018 [PMID: 30069950] (WB, Human) WB Human
Wang Y, Zhou Y, Jin L et al. Mineral trioxide aggregate enhances the osteogenic capacity of periodontal ligament stem cells via NF-kB and MAPK signaling pathways J. Cell. Physiol. 2017 Jul 27 [PMID: 28749049] (WB, Human) WB Human
Paudel U, Lee YH, Kwon TH et al. Eckols reduce dental pulp inflammation through the ERK1/2 pathway independent of COX-2 inhibition Oral Dis. 2014 Jun 13 [PMID: 24924779] (WB, Human)

Details:
Dentin matrix acidic phosphoprotein-1 /DMP1 antibody used for WB on lipopolysaccharide (LPS) stimulated human dental pulp cells/ HDPCs cultures treated or not with 10uM of 6-6 bieckol/EB1 or pholorofucofuroeckol-A /EB5 isolated from browin seaweed marine algae - Eisenia bicyclis (Figure 4 a)
WB Human
Li J, Yan M, Wang Z et al. Effects of Canonical NF- kappaB Signaling Pathway on the Proliferation and Odonto/Osteogenic Differentiation of Human Stem Cells from Apical Papilla. Biomed Res Int. 2014 May 27 [PMID: 24864235] (WB, Human) WB Human

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol DMP1
Entrez
Uniprot