DMAP1 Antibody (2G12)

Product Discontinued

DMAP1 Antibody (2G12) Summary

• Immunogen: DMAP1 (NP_061973, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag.MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPF
• Specificity: DMAP1 (2G12)
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: DMAP1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1:500
• Application Notes: Antibody reactive against transfected lysate and recombinant protein for western blot. It has also been used for ELISA.

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DMAP1 Antibody (2G12)

• DNA methyltransferase 1 associated protein 1
• DNA methyltransferase 1-associated protein 1
• DNMAP1DNMT1-associated protein 1
• DNMT1 associated protein 1
• DNMTAP1
• EAF2
• FLJ11543
• KIAA1425DKFZp686L09142
• MEAF2
• SWC4

Background

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DMAP1 Antibody (H00055929-M01)(1)

Publication using H00055929-M01

• Yamaguchi Y, Takenobu H, Ohira M et al. Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. Eur J Cancer. 2014-02-19 [PMID: 24559687]

Bioinformatics

• Gene Symbol: DMAP1
• Entrez:
  • 55929(Human)
• OMIM:
  • 605077(Human)
• Uniprot:
  • NP_061973(Human)