Dfna5 Antibody

Immunohistochemistry: Dfna5 Antibody [NB110-75027] - IHC on mouse brain using Rabbit antibody to mouse Dfna5 (non-syndromic hearing impairment protein 5 homolog): whole serum at 1 : 500 dilution, incubated overnight and developed with DAB Ni. Nerve fibers are intensely stained.

Immunohistochemistry: Dfna5 Antibody [NB110-75027] - IHC on mouse brain using Rabbit antibody to mouse Dfna5 (non-syndromic hearing impairment protein 5 homolog): whole serum at 1 : 500 dilution, incubated overnight and developed with DAB Ni. Nerve fibers are intensely stained.

Product Discontinued

Dfna5 Antibody Summary

• Immunogen: A synthetic peptide as a internal part of mouse Dfna5 (non-syndromic hearing impairment protein 5 homolog) conjugated to immunogenic carrier protein was used as the immunogen.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GSDME
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:300-1:3000

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for Dfna5 Antibody

• deafness, autosomal dominant 5
• DFNA5, deafness associated tumor suppressor
• gasdermin-E
• ICERE1
• ICERE-1
• Inversely correlated with estrogen receptor expression 1
• non-syndromic hearing impairment protein 5
• nonsyndromic hearing impairment protein

Background

Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GSDME
• Entrez:
  • 1687(Human)
  • 54722(Mouse)
• Uniprot:
  • Q9Z2D3(Mouse)