Cytokeratin 17 Antibody (Ks 17.E3)

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, IHC, IHC-Fr, IHC-P
Clone
Ks 17.E3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Cytokeratin 17 Antibody (Ks 17.E3) Summary

Immunogen
The antibody reacts with the Keratin 17 antigen.
Specificity
This antibody represents an excellent marker to distinguish myoepithelial cells from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and benign from malignant forms of e.g. mammary gland tumors. Most malignant forms of mammary tumors are negative for cytokeratin 17. Antigen: Human cytokeratin 17 of Mr 46,000 Antigen recognized in species: Human and rat (Mr 40,000 polypeptide)
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
KRT17
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Suitable for frozen tissue, cytological material, immunoblotting (Western blot). Also suitable for paraffin-embedded tissue when using the MICROWAVE method.Working dilution: Dilute approximately 1:10 with PBS pH 7.4 for immunohistochemical application (ABC method); optimal working dilution should be determined by serial dilution prior to application.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
No Preservative
Purity
Protein A or G purified
Reconstitution Instructions
Reconstitute with 1.0 ml sterilized distilled water to desired concentration.

Alternate Names for Cytokeratin 17 Antibody (Ks 17.E3)

  • 39.1
  • CK-17
  • cytokeratin-17
  • K17
  • keratin 17
  • keratin, type I cytoskeletal 17
  • keratin-17
  • PC
  • PC2
  • PCHC1

Background

Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells. Cytokeratin is a heterotetramer of two type I and two type II keratins. Keratin 1 is generally associated with keratin 10. Defects in Cytokeratin are a cause of epidermolytic hyperkeratosis, also known as bullous congenital ichthyosiform erythroderma (BIE), which is a hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. Defects in Cytokeratin are also the cause of Curth Macklin type ichthyosis hystrix, nonepidermolytic palmoplantar keratoderma, annular epidermolytic ichthyosis and keratosis palmoplantaris striata III (PPKS3). PPKS3 is an autosomal dominant disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of nonpalmoplantar skin, and both hair and nails are normal.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KRT17